Table 2 Baseline demographic and clinical characteristic ANOVA group comparisons of mixed and hypo-cholinergic against the hyper-cholinergic subgroup

From: A multicenter longitudinal study of cholinergic subgroups in Parkinson disease

Variable

Hyper-cholinergic

(N = 71)

Mixed-cholinergic

(N = 100)

Hypo-cholinergic

(N = 74)

Model

P value

Age

(years)

65.66

[63.8, 67.53]

67.55

[65.98, 69.12]

66.99

[65.16, 68.81]

0.3088

MoCA

(score)

25.86

[25.1, 26.61]

25.77

[25.13, 26.41]

25.53

[24.78, 26.28]

0.8155

Disease duration

(years)

3.47

[2.41, 4.53]

4.46

[3.61, 5.31]

5.25*

[4.26, 6.24]

0.0552

PIGD severity

(score)

0.14

[0.11, 0.17]

0.17

[0.15, 0.2]

0.18

[0.14, 0.21]

0.2213

MDS-UPDRS part II

(total score)

8.18

[6.85, 9.52]

8.61

[7.48, 9.74]

8.08

[6.75, 9.41]

0.8107

MDS-UPDRS part III

(total score)

30.84

[27.7, 33.98]

35.37*

[32.73, 38.01]

38.53*

[35.48, 41.59]

0.0028*

Hoehn & Yahr

(score)

1.94

[1.79, 2.1]

2.24*

[2.11, 2.38]

2.39*

[2.23, 2.54]

<0.001*

  1. Estimated marginal means with 95% intervals for each variable are presented by subgroup (regression coefficients corresponding to group contrasts for which the confidence interval did not overlap with 0 are marked with an asterisk). Model P values are presented for the ANOVA group comparisons and were considered statistically significant at Bonferonni adjusted two-tailed α = 0.00714 (0.05 / 7 comparisons), in which case they were marked with an asterisk.
  2. MoCA Montreal Cognitive Assessment, PIGD postural instability and gait difficulty, MDS-UPDRS Movement Disorder Society Revised Unified Parkinson’s Disease Rating Scale.
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