Fig. 3: Retroviral and lentiviral-transduced cell engraftment kinetics in patient NYSCT-05. | Nature Communications

Fig. 3: Retroviral and lentiviral-transduced cell engraftment kinetics in patient NYSCT-05.

From: Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny

Fig. 3

A Peripheral TCR+ expansion and contraction over time in vivo. B Vector copy number (VCN) kinetics in peripheral circulation. While there was a predominance of retrovirus (RV)-derived product early, there was no significant detectable lentiviral (LV) progeny at any point, consistent with the non-engraftment observed which was observed at the day +35 [18 F]-FHBG PET scan (C). Data in 3B represent two experimental replicates, ± SD.

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