Fig. 2: Synthesis and characterization of Mg-ALN. | Nature Communications

Fig. 2: Synthesis and characterization of Mg-ALN.

From: Injectable magnesium-bisphosphonate MOF-based bone adhesive prevents excessive fibrosis for osteoporotic fracture repair

Fig. 2

a Optical microscopy image showing the distribution of Mg-ALN in water, scale bar: 10 μm. b TEM images and elemental distribution of Mg-ALN, scale bar: 500 nm. c EDS analysis of Mg-ALN. d Sizes distribution of Mg-ALN. e AFM thickness analysis of Mg-ALN, scale bar: 500 nm. f XRD pattern and rietveld refinement results for Mg-ALN. g Coordination unit and crystal structure images of Mg-ALN. h Drug loading of ALN in Mg-ALN synthesized with different ALN and Mg2+ molar ratios, Center lines represent median expressions, the top and bottom edges of the box represent the 75th percentile (upper quartile) and 25th percentile (lower quartile), and whiskers represent the minimal and maximal values (n = 3 independent samples). i pH changes during the acid-titration experiment with Mg-ALN. Mg2+ ( j) and ALN (k) release from Mg-ALN at different time points upon incubation at pH 4.5, 6.8, or 7.4 (n = 3 independent samples). l The disc size changes of Mg-ALN after incubation for 7 days at pH 4.5, 6.8 or 7.4 were analyzed by laser diffraction and transmission electron microscopy, scale bar: 500 nm. Three independent experiments were performed and representative results are shown in (a, b, e, l). Data are presented as mean values ± SEM. Source data are provided as a Source Data file.

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