Fig. 5: Real-time identification and biomechanical analysis of aggregates using SDM and IC-LINA. | Nature Communications

Fig. 5: Real-time identification and biomechanical analysis of aggregates using SDM and IC-LINA.

From: Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging

Fig. 5

The IC-LINA model detects in real time the presence of aggregates solely from label-free brightfield images, eliminating the need for fluorescence imaging to localize aggregates. Here, the fluorescence image serves as a ground truth to validate aggregate presence. Autonomously-triggered Brillouin microscopy enables detailed biomechanical analysis at identified locations. Images are representative of experiments conducted more than three independent times. Scale bars: 5 µm.

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