Fig. 4: Merged network links SARS-CoV-2 to neurological and druggable host factors. | Nature Communications

Fig. 4: Merged network links SARS-CoV-2 to neurological and druggable host factors.

From: Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids

Fig. 4

a Spearman correlation between SARS-CoV-2 viral protein pairs based on their shared human proteins in the merged (AP-MS and CF-MS) network. b Sankey plot showing shared host proteins among the correlated SARS-CoV-2 viral proteins from a. c GO biological term enrichment for host factors shared among correlated viral proteins in b. P-values from one-sided Fisher’s exact test and adjusted for FDR ≤ 5e−2 with the BH method. d Analysis of SARS-CoV-2-host PPIs (n = 1279) in M0 and M1 macrophages and N9 mouse microglia (human orthologs) vs. SARS-CoV-2 patient saliva. e Host-viral PPIs detected in M1 macrophages and/or microglia but absent in SARS-CoV-2 patient saliva are linked to neuroinflammation and neurological disorders. f Predicted MPCs (n = 173) showing SARS-CoV-2 (yellow rhombus) and human (gray circle) proteins, with potential drug targets highlighted in red circle or rhombus. Viral-host PPIs are represented by green lines. Zoomed-in views of selected MPCs illustrate both established (dashed lines) and new (thick lines) interactions. g Human MPC subunits interacting with SARS-CoV-2 proteins are targeted by at least one of 7626 drugs from DrugBank. h Heatmap of 13 drugs targeting 10 or more human host factors across 52 MPCs, with each MPC subunit targeted by at least two drugs. Source data are provided as a Source Data file.

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