Fig. 6: Application of SigXTalk to the time-resolved mouse lung dataset.
From: Dissecting crosstalk induced by cell-cell communication using single-cell transcriptomic data
a. The experimental process of bleomycin injury on mouse lung cells. Cells are visualized using Uniform Manifold Approximation and Projection (UMAP); b. The bar chart that visualizes the number of activated ligand-receptor interactions (LRIs) regarding Krt8 ADI cells at different time points; c. The number of crosstalk pathways that pass through the SSCs at each time point. The SSCs within each time point are ranked according to the numbers of crosstalk pathways. The top-3 SSCs with most crosstalk pathways are highlighted in the inner panel; d. The probability distribution of all the fidelity values at each time point. The average fidelity at each time point is highlighted in the inner panel; e. The circle plots of the top-20 pathways with the highest PRS values at each time point; f. The heatmaps of the fidelity and specificity of crosstalk pathways regulating Actb at different time points. Here, the fidelity or specificity is calculated based on the crosstalk module containing pathways with common SSC + Target or Signal + SSC, respectively. Source data are provided as a Source Data file.
