Fig. 1: Comprehensive single-cell molecular profiling of dup15q syndrome using postmortem cortical samples and cortical organoids. | Nature Communications

Fig. 1: Comprehensive single-cell molecular profiling of dup15q syndrome using postmortem cortical samples and cortical organoids.

From: Single-cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism

Fig. 1: Comprehensive single-cell molecular profiling of dup15q syndrome using postmortem cortical samples and cortical organoids.The alternative text for this image may have been generated using AI.

a Illustration of experimental design, sample collection, and cell capture. Some elements were created in BioRender. Perez, J. (2025) https://BioRender.com/nvvwyh3. b G-banding karyotype of normal and idic(15q) iPSC lines. c Unbiased clustering of single nuclei and annotated cell types of postmortem samples. Some elements were created in BioRender. Perez, J. (2025) https://BioRender.com/6z5et7u. d Unbiased clustering of cortical organoid single cells and annotated cell types. Some elements were created in BioRender. Perez, J. (2025) https://BioRender.com/rpjlezb. e Primary nuclei clustered by genotype, showing equal contribution of dup15q and control samples to all cell types. f Organoid cells clustered by genotype, showing similar contributions from dup15q and control organoids to all cell types. g Cell-type-specific average expression of the duplicated genes within the PWACR region in primary and organoid cells.

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