Fig. 1: Pregnancy outcomes following PEARS in women with heritable thoracic aortic disease. | Nature Communications

Fig. 1: Pregnancy outcomes following PEARS in women with heritable thoracic aortic disease.

From: Connective tissue disorder and high risk pregnancy: a case series with personalised external aortic root support (PEARS)

Fig. 1

Schematic overview of pregnancy outcomes in women with Marfan syndrome (n = 6) and Loeys–Dietz syndrome (n = 1) following the PEARS procedure. Indication for PEARS was aortic root dilatation ≥45 mm (4 patients) and anticipation of pregnancy (3 patients). Mean age at the time of PEARS was 26.8 ± 6.9 years with the median interval between PEARS and confirmed pregnancy 2.6 (1.2–15.6) years. All 9 pregnancies were successful. Delivery methods included 6 Cesarean sections (5 elective, 1 emergency) and 3 vaginal deliveries. During a mean follow-up of 4.3 years (range: 2 months–14.8 years) after delivery, there were no type A or B aortic dissections, and aortic dimensions remained stable. PEARS Personalized External Aortic Root Support. Created in BioRender. Kacar, M. (2025) https://BioRender.com/k9f5hko.

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