Fig. 9: Functional activity of HLA molecules in ABab-I mice.
From: Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules
A List of TCRs restricted towards HLA molecules in ABab-I mice with known peptide binders were used in presentation assays. B Ex vivo-isolated peripheral blood cells or cells from lymphoid organs from ABab-I mice, co-cultured with TCR-transduced or untransduced T cells. Cytokine levels were measured after 16 h of co-culture by mouse IFN-γ ELISA assay. Consolidated data from multiple TCR co-culture experiments are shown, grouped by HLA restriction and ex vivo tissue source as follows: A*03:01, n = 6 (peripheral blood), n = 6 (lymphoid organs); A*11:01, n = 12 and 3; B*07:02, n = 12 and 6; B*15:01, n = 10 and 3; C*04:01, n = 4 and 3; C*07:02, n = 12 and 3, respectively. Data in (B) are presented as mean ± SD. Source data are available in the Source Data file.
