Fig. 1: Combined Manhattan/Miami plots of traits with genome-wide significant variants showing overall and sex-stratified association results.
The x axis represents chromosomal positions of variants, and the y axis the negative log10-transformed p values from two-sided linear regression tests of association. The genome-wide significance threshold (5 × 10−8) is shown as a red dashed line. A stricter significance threshold (3.85 × 10−9) accounting for the 13 investigated traits is shown as a red dotted line. Variants with genome-wide significance are coloured according to their associated trait. Index variants are annotated with a locus identifier and proposed candidate genes, if applicable. Annotations within boxes indicate novel loci. Bold labels indicate significant sex interactions (qSIA < 0.05). Loci in parentheses are not considered independent. Labels are positioned according to the analysis group with the strongest association of the respective index variant. SNPs with −log10(p) < 2 are not shown. SNPs with −log10(p) > 20 are shown with a truncated value of 20.
