Table 1 Loci with trait-wise genome-wide significance that are associated with olfactory identification

Locus number	Index variant	Cytoband/ Base position	Top association	AA/EA	N-weighted MAF	Beta (SE)	P value	N	Additional associated phenotypes	Proposed candidate gene(s)	q value sex interaction
1	rs73252922	4q12/53988378	fish all	A/C	0.0311	−0.5391 (0.0985)	4.43 × 10⁻⁸	18632		FIP1L1/GSX2	0.69
2	*rs116058752*	5p15.31/7705328	orange female	A/G	0.0293	1.0561 (0.1790)	3.66 × 10⁻⁹	9984		ADCY2	3.42 × 10⁻³
3	rs17161232	5q21.3/108318249	lemon all	A/T	0.1847	0.1589 (0.0288)	3.38 × 10⁻⁸	18678		FBXL17	0.69
4	*rs3117345*	6p22.1/29234688	cinnamon all	A/G	0.4720	−0.2587 (0.0257)	8.14 × 10⁻²⁴	18690	cinnamon female cinnamon male	OR-Cluster (OR2)	0.74
5	rs41286168	6q23.2/132589404	fish all	A/G	0.0126	−1.3237 (0.1580)	5.39 × 10⁻¹⁷	18686		TAAR5	0.14
6	rs317787	11p15.4/5504313	cinnamon all	T/C	0.3276	−0.3195 (0.0266)	3.21 × 10⁻³³	18690	cinnamon male cinnamon female	OR-Cluster (OR51/OR52)	0.09
7*	rs11245786*	11p11.12/50656667	pineapple all	A/G	0.2204	0.1716 (0.0291)	3.90 × 10⁻⁹	18651
8	*rs669453*	11q12.1/56493175	pineapple all	A/C	0.3236	−0.2964 (0.0256)	4.91 × 10⁻³¹	18686	pineapple female pineapple male score all	OR-Cluster (OR5)	0.78
9	rs61902559	11q12.1/59415292	pineapple all	T/C	0.2963	−0.2138 (0.0253)	2.74 × 10⁻¹⁷	18679	pineapple male	OR-Cluster (OR5)	0.02
10	rs56320200	13q14.3/50906784	cinnamon female	A/C	0.4055	−0.1855 (0.0337)	3.69 × 10⁻⁸	10000			2.08 × 10⁻⁵
11	*rs2318888*	14q11.2/20201081	pineapple all	T/C	0.2818	−0.1801 (0.0253)	1.06 × 10^–12	18688	pineapple female	OR-Cluster (OR11)	0.13

Association statistics and two-sided p values of β-coefficients of the additive genetic effects are provided for the strongest association of each locus (index variant, minimum p value). The top association column reports the combination of trait and analysis group (all, male, female) corresponding to this association. Novel loci are presented in bold while significant sex interactions (two-sided) are underlined. Italicised loci fulfil a stricter study-wide significance threshold of p < 3.85 × 10⁻⁹, resulting from additional Bonferroni correction on the 13 investigated traits. For clusters of olfactory receptors, the most abundant OR family is provided in parentheses. For independent loci, the q values (FDR-corrected p values) for SNP-by-sex interaction of the index variant are shown. *Locus 7 was identified as not independent of locus 8 after locus definition. MAF minor allele frequency, AA alternative allele, EA effect allele, SE standard error, N sample size.

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