Fig. 1: Asymmetric hydrogenation of 1,3-diketones. | Nature Communications

Fig. 1: Asymmetric hydrogenation of 1,3-diketones.

From: SPA-PNN ligand for the kinetic resolution of carbocyclic and heterocyclic spiranes by asymmetric hydrogenation

Fig. 1

a Previous work: desymmetric enantioselective reduction of monocyclic 1,3-diketones via asymmetric hydrogenation (AH). b Challenging kinetic resolution of spirocyclic 1,3-diketones via AH. c This work: kinetic resolution of spirocyclic 1,3-diketones and heterocyclic spiranes via AH. d Representative spirocyclic natural products. e Selected chiral ligands and materials containing the spirocyclic structural motif.

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