Fig. 1: Dextran sulfate sodium (DSS)-induced chronic colitis and fibrosis upregulates plasma aldosterone and mineralocorticoid receptor (MR) activation. | Nature Communications

Fig. 1: Dextran sulfate sodium (DSS)-induced chronic colitis and fibrosis upregulates plasma aldosterone and mineralocorticoid receptor (MR) activation.

From: Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models

Fig. 1

Male C57BL/6 J mice underwent 3 cycles of 2% DSS in their drinking water for 7 days, followed by 14 days of regular water (DSS; n = 11) whereas control mice received normal water (CT; n = 10). a Experimental design. b Plasma aldosterone level (n = 10 for CT, n = 11 for DSS; Two-sided Mann-Whitney test). c, d Representative western blot and relative protein expression of colon MR (c, n = 10 for CT, n = 11 for DSS; Two-sided Mann-Whitney test) and SGK1 (d, n = 9 for CT, n = 12 for DSS; Two-sided unpaired t-test with Welch’s correction). GAPDH is used as an internal control. Data are presented as mean values +/− SEM. Created in BioRender67.

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