Fig. 9: Effect of genetic deletion of neutrophil gelatinase-associated lipocalin (NGAL) on colon mineralocorticoid receptor (MR) and SGK1 expression in female mice with dextran sulfate sodium (DSS)-induced colitis. | Nature Communications

Fig. 9: Effect of genetic deletion of neutrophil gelatinase-associated lipocalin (NGAL) on colon mineralocorticoid receptor (MR) and SGK1 expression in female mice with dextran sulfate sodium (DSS)-induced colitis.

From: Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models

Fig. 9

Female C57BL/6 DSS-NGAL−/− (n = 13) and DSS (n = 8) underwent 3 cycles of 2% DSS in their drinking water for 7 days, followed by 14 days of regular water for both first cycles and 7 days for the third cycle. Control mice received normal water (CT; n = 10). a, b Representative western and relative protein level of MR (a) and SGK1 (b) colon (n = 5 for CT, n = 8 for DSS, n = 11 for DSS-NGAL−/−; Kruskal-Wallis test with Dunn’s multiple comparisons test). Data are presented as mean values +/− SEM.

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