Fig. 6: C32E8.9 mediates lipidomic changes taking place under mitochondrial translation inhibition. | Nature Communications

Fig. 6: C32E8.9 mediates lipidomic changes taking place under mitochondrial translation inhibition.

From: Immuno-metabolic stress responses control longevity from mitochondrial translation inhibition in C. elegans

Fig. 6: C32E8.9 mediates lipidomic changes taking place under mitochondrial translation inhibition.

a Bar plot of enriched gene sets in genes interacting with C32E8.9 in C. elegans annotated in GeneMANIA. b PCA plot of the lipidome. c Lipid classes enrichment analysis of lipids significantly upregulated in mrps-5 RNAi vs control (adjusted p-value < 0.05, absolute log2FC > 1), NES represents ‘Normalized Enrichment Score.’ d Lipid class over-representation analysis of lipids significantly downregulated (adjusted p-value < 0.05, absolute log2FC < −1) in mrps-5 + C32E8.9 double RNAi vs mrps-5 RNAi. e Bar plot of the number of significantly altered lipids (adjusted p-value < 0.05, absolute log2FC > 1) in different comparisons. f Dot plot of significantly changed TGs in mrps-5 + C32E8.9 double RNAi vs mrps-5 RNAi comparison. g Dot plot of significantly changed DGs in mrps-5 + C32E8.9 double RNAi vs mrps-5 RNAi comparison. h Dot plot of significantly changed PCs in mrps-5 + C32E8.9 double RNAi vs mrps-5 RNAi comparison. For (f–h), X-axis represents the length of the individual TG species. Y-axis represents the number of double bonds in each of the TG species.

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