Fig. 7: Overexpressing C32E8.9 partially mimics the beneficial effect of mitochondrial translation inhibition. | Nature Communications

Fig. 7: Overexpressing C32E8.9 partially mimics the beneficial effect of mitochondrial translation inhibition.

From: Immuno-metabolic stress responses control longevity from mitochondrial translation inhibition in C. elegans

Fig. 7: Overexpressing C32E8.9 partially mimics the beneficial effect of mitochondrial translation inhibition.

a Lifespan curves of control worms (N2 background strain) and C32E8.9 expression strain (OE) cultured with OP50. 195 worms were analyzed per condition, with data collected from two independent replicate experiments, as specified in Supplementary Data 1. b Survival curves of slow-killing assay (chronic P. aeruginosa PA01 infection) of control worms (N2 background strain) and C32E8.9 expression strain (OE). 168–170 worms were analyzed per condition across two independent experimental replicates, as detailed in Supplementary Table S1. For (a) and (b), p-values were calculated using the log-rank test to compare each condition with the corresponding control. Statistical significance is indicated as follows: ** represents p-value < 0.01, * represents p-value < 0.05. c Hypothetical scheme depicting how immuno-metabolic stress response orchestrated by C32E8.9 contributes to longevity from mitochondrial translation.

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