Fig. 6: M1-mutIL-18 promotes directed clonal expansion of CD8+ T cells. | Nature Communications

Fig. 6: M1-mutIL-18 promotes directed clonal expansion of CD8+ T cells.

From: Suppression of multiple mouse models of refractory malignancies by reprogramming IL-18 ligand-receptor interaction

Fig. 6

a Clonal expansion of different cluster in CD8+ T cells. b Changes in TCR in CD8+ T cells in each group. c Clonal number of the top 15 TCRs in all groups. d Sequences of the most expanded TCRs across treatment conditions. e Distribution of clonally expanded CD8+ T cells. f Changes of differentiation in the top 15 TCRs in all groups. g Differential gene enrichment analysis of CD8+ T cells with top3 TCRs compared to CD8+ T cells without top3 TCRs in the M1-mutIL-18 group. P-values were calculated using Fisher’s exact test and adjustments were made for multiple comparisons (g).

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