Table 3 Median microfilarial density (MFD), and median relative difference in MFD between DX (X = 3, 5, 7, 15, or 30) and D1 (pre-treatment) by arm (intention-to-treat analysis)
Arms | P | ||||||
|---|---|---|---|---|---|---|---|
Median and Interquartile Ranges (IQR) of L. loa MFD (mf/mL) | |||||||
Day | PLA (N = 30) | LEV-3 (N = 33) | LEV-5 (N = 28) | a | b | c | d |
D1 | 13,475 (7780; 23,805) | 12,775 (5695; 24,675) | 11,817 (6882; 24,635) | 0.613 | 0.549 | 0.422 | 0.474 |
D3 | 12,737 (8098; 35,570) | 7430 (3290; 12,990) | 6,942 (3982; 13,905) | 0.004 | 0.004 | 0.007 | 0.412 |
D5 | 15,195 (7500; 24,725) | 9555 (3745; 13,670) | 5,227 (2527; 10,555) | 0.001 | 0.009 | <0.001 | 0.145 |
D7 | 15,187 (9567; 30,832) | 9940 (3855; 12,645) | 5,902 (1985; 17,520) | 0.009 | 0.021 | 0.006 | 0.207 |
D15 | 13,315 (8020; 32,215) | 10,515 (5315; 19,030) | 7,927 (5127; 16,935) | 0.050 | 0.072 | 0.029 | 0.265 |
D30 | 13,802 (7065; 37,390) | 13,600 (6030; 20,555) | 7,287 (5272; 15,102) | 0.073 | 0.131 | 0.033 | 0.215 |
Median and IQR of the reduction of L. loa MFD compared to the pre-treatment result (%) | |||||||
Day | PLA (N = 30) | LEV-3 (N = 33) | LEV-5 (N = 28) | a | b | c | d |
D3 | 0.4 (−9.4; 19.3) | 35.8 (19.1; 52.8) | 34.4 (23.3; 48.3) | <0.001 | <0.001 | <0.001 | 0.496 |
D5 | −1.6 (−18.5; 16.7) | 29.3 (11.7; 58.1) | 51.4 (20.0; 63.5) | <0.001 | <0.001 | <0.001 | 0.048 |
D7 | 8.2 (−13.2; 19.0) | 24.3 (12.1; 51.0) | 34.4 (25.5; 62.9) | <0.001 | 0.004 | <0.001 | 0.035 |
D15 | −10.1 (−35.8; 14.9) | 16.0 (−26.2; 38.3) | 15.4 (5.4; 41.0) | 0.009 | 0.039 | 0.004 | 0.149 |
D30 | −1.3 (−34.7; 20.9) | 2.0 (−20; 35.7) | 17.7 (0.5; 45.9) | 0.040 | 0.149 | 0.017 | 0.119 |
