Fig. 4: Enhanced metabolic heterogeneity of mycobacterial bacilli due to trehalose catalytic shift activity. | Nature Communications

Fig. 4: Enhanced metabolic heterogeneity of mycobacterial bacilli due to trehalose catalytic shift activity.

From: Trehalose catalytic shift inherently enhances phenotypic heterogeneity and multidrug resistance in Mycobacterium tuberculosis

Fig. 4: Enhanced metabolic heterogeneity of mycobacterial bacilli due to trehalose catalytic shift activity.

RMR-tre fluorescence labeling patterns are shown for A wildtype M. smegmatis, B ItreSSM, and C pTreSSM (M. smegmatis overexpressing TreS) following treatment with a sublethal dose of RIF. The bacilli within the area labeled R1 are defined as the RMR-trehigh subfraction. Additionally, the RMR-tre fluorescence labeling patterns for D a representative FluxRIF bacillus, and E its CRISPRi treS knockdown strain after ATc treatment, are depicted.

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