Table 1 Antibacterial and cytotoxicity properties of OIM compounds
No. | Oligomer | Minimum inhibitory concentration, MIC (µg/mL) | Geometric mean of IC50a (µg/mL) | Selectivity index, SIb | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
S. aureus ATCC 29213 (+) | E. faecium ATCC 19434 (+) | K. pneumoniae ATCC 13883 (−) | A. baumannii ATCC 19606 (−) | P. aeruginosa PAO1 (−) | E. coli MG1655 (−) | E. cloacae ATCC 13047 (−) | Geometric mean (Geo-MIC) | 24-h (Geo-IC50,24) | 72-h (Geo-IC50,72) | Geo-IC50,24/Geo-MIC | Geo-IC50,72/Geo-MIC | ||
1 | OIM1-6-CH | 1−2 | 2 | 4 | 4 | 2−4 | 4 | 16−32 | 4.0 | >1024 | 57.7 | >256.0 | 14.4 |
2 | OIM1-6-C2(CH3) | 256 | >512 | 256 | 128 | 128 | 512 | >512 | 344.6 | 1002.2 | >1024 | 2.9 | >3.0 |
3 | OIM1-6-C2(Cl) | 16 | >512 | 32 | 32 | 256 | 64−128 | 256−512 | 118.5 | 748.6 | 479.7 | 6.3 | 4.0 |
4 | OIM1-6-C2(CF3) | 32 | >512 | 64 | 64 | 128 | 128 | 256 | 128.0 | 693.4 | 727.0 | 5.4 | 5.7 |
5 | OIM1-6-C4(CH3) | 2−4 | 8 | 16 | 16 | 8−16 | 8 | 64 | 10.1 | >1024 | 675.3 | >101.4 | 66.9 |
6 | OIM1-6-C4(Cl) | 2 | 4 | 4 | 8 | 4 | 4 | 8 | 4.4 | ≥1024 | 267.5 | ≥232.7 | 60.8 |
7 | OIM1-6-C4(F) | 2 | 32 | 16 | 4 | 32 | 32 | 64 | 16.0 | 365.1 | 66.9 | 22.8 | 4.2 |
8 | OIM-1-6-(BZ) | 8 | 64 | 8 | 64 | 64 | 8 | 32 | 23.8 | 39.5 | 135.8 | 1.7 | 5.7 |
9 | OIM1-8-CH | 2 | 8 | 4 | 2−4 | 2 | 4 | 4 | 3.4 | 385.1 | 31.3 | 113.3 | 9.2 |
10 | OIM1-8-C2(CH3) | 8 | >512 | 32 | 16 | 32 | 32 | 64 | 43.1 | 835.5 | 781.6 | 19.4 | 18.1 |
11 | OIM1-8-C4(CH3) | 2 | 4−8 | 4 | 2−4 | 2 | 4 | 4 | 3.4 | >1024 | 387.2 | >301.2 | 113.9 |
12 | OIM1-8-2D | 2 | 4 | 2 | 4 | 16 | 8 | 8 | 4.9 | 758.9 | 419.5 | 154.9 | 85.6 |
13 | OIM1-8-2D-4NBZate | 4 | 16 | 4 | 4 | 8 | 8 | 16 | 7.3 | 1000.5 | 720.0 | 137.0 | 98.6 |
14 | Gentamicin | ≤1 | 64 | ≤1 | 8 | ≤1 | ≤1 | ≤1 | 2.4 | >1024 | >1024 | >426.7 | >426.7 |
15 | Colistin | 128 | >512 | 8 | 2 | 2 | 2 | 512 | 23.8 | 791.4 | 630.5 | 33.3 | 26.5 |
16 | Ciprofloxacin | 1−2 | 4 | ≤1 | ≤1 | ≤1 | ≤1 | ≤1 | 1.3 | 187.2 | 202.2 | 144.0 | 155.6 |
