Table 2 Antibacterial potency of OIM1-6 series compounds compared to the activity of antibiotics against a panel of multi-drug-resistant (MDR) bacteria
MIC of oligomers/antibiotics (µg/mL) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Bacteria (Gram-positive) | OIM1-6-CH (1) | OIM1-6-C2 (CH3) (2) | OIM1-6-C4 (CH3) (5) | OIM1-8-2D (12) | OIM1-8-2D-4NBZate (13) | Imipenem | Vancomycin | Colistin | Gentamicin |
S. aureus USA300 (MRSA) | 2 | 512 | 4–8 | 2 | 4 | 0.25–0.5 | 1–2 | 256 | 1 |
S. aureus (LAC) | 2 | 128 | 4 | 2 | 4 | ≤0.25 | 1 | 64 | ≤1 |
S. aureus (LAC*) | 2 | 64 | 4 | 8 | 4 | ≤0.25 | 0.5–1 | >512 | ≤1 |
S. aureus MRSA BAA 39 | 2 | 512 | 4 | 2 | 4 | ≤0.25 | 1 | 128 | 256 |
E. faecalis 583 (VRE)a | 32–64/2 | >512/>512 | 128/8 | 16/4 | 8/4 | 1 | 8/16 | >512/>512 | >512/>512 |
S. epidermidis (MRSE 700563) | 1 | 32 | 1 | 4 | 2 | 1 | 2 | 128 | ≤0.5 |
Bacteria (Gram-negative) | |||||||||
A. baumannii BAA 2803 | 2 | 32 | 8 | 2 | 4–8 | 32–64 | 64 | 4 | >512 |
A. baumannii AB-1 (MDR) | 2 | 128 | 8 | 4 | 8 | 32–64 | 128–256 | 2 | >512 |
B. thailandensis 700388 | 8 | >512 | >512 | 16 | 64–128 | ≤0.25 | >256 | >512 | 64 |
E. coli NMT 1833 | 2 | 256 | 8 | 16 | 16 | 16-32 | 256 | 4 | 1 |
E. coli 958 (MDR) | 4 | 1024 | 8 | 16 | 16 | ≤0.25 | 256 | 2 | 2 |
E. coli BAA 2774 | 4 | 128 | 2 | 8 | 16 | ≤0.25 | 256 | 2 | 32 |
E. coli UTI89 | 4 | ≥512 | 16 | 16 | 16 | ≤0.25 | 128–256 | 2 | 0.5 |
E. cloacae 13047-MDR | 4 | >512 | 32 | 8 | 16 | 1 | >256 | 128 | ≤1 |
K. pneumoniae (KPNR) | 2 | 256 | 2 | 4 | 8 | 8 | >256 | 2 | >512 |
K. pneumoniae SGH 10 | 2 | 32 | 4 | 2 | 8 | 0.25–0.5 | >256 | 2 | 2 |
P. aeruginosa BAA 2797 | 4 | >512 | 32 | 16 | 32 | 256 | >256 | 2 | >512 |
P. aeruginosa PAER | 4 | 64 | 16 | 16 | 32 | >256 | >256 | 2 | 128 |
S. marcescens ATCC 13880 | 4 | >512 | 32 | 16 | 32 | 0.5–1 | >256 | 256 | 2 |
Geometric mean (Geo-MIC) | 3.5 | 265.0 | 10.1 | 7.4 | 10.6 | 2.3 | 39.5 | 26.9 | 20.4 |
