Fig. 3: Construction of phosphine-containing 1,2,3-trisubstituted cyclobutane scaffoldsa,b. | Nature Communications

Fig. 3: Construction of phosphine-containing 1,2,3-trisubstituted cyclobutane scaffoldsa,b.

From: Diastereoselective synthesis of multi-substituted cyclobutanes via catalyst-controlled regiodivergent hydrophosphination of acyl bicyclobutanes

Fig. 3: Construction of phosphine-containing 1,2,3-trisubstituted cyclobutane scaffoldsa,b.The alternative text for this image may have been generated using AI.

aConditions B: 0.2 mmol BCB 1, 2.0 equiv. diphenyl phosphine, 1.0 equiv. LiBr and 10 mol% CuBr2 in 2.0 mL DMF at 60 °C for 24 h. bIsolated yield. c1.0 mmol scale, 4a: d.r. = 15:1.dRun at 25 °C.

Back to article page