Table 1 . Initial experiments and optimization
From: Cobalt catalyst with exclusive metal-centered chirality for asymmetric photocatalysis
| |||||
|---|---|---|---|---|---|
entry | catalyst (mol%) | conditionsa | T/[°C] | yieldb | ee (%)c |
1 | Δ-CoCat1 (3) | light | r.t. | 90 | 0 |
2 | Δ-CoCat1 (3) | no light | r.t. | trace | - |
3 | Δ-CoCat1 (3) | light | −30 | 9 | 2 (R) |
4 | Δ-CoCat2 (3) | light | −30 | 23 | 42 (R) |
5 | Δ-CoCat3 (3) | light | −30 | 93 | 64 (R) |
6 | Δ-CoCat3 (3) | light | −45 | 82 | 82 (R) |
7 | Δ-CoCat3 (3) | light | −50 | 58 | 83 (R) |
8 | Δ-CoCat3 (3) | light, NaBArFd | −50 | 96 | 80 (R) |
9 | Δ-CoCat3 (6) | light, NaBArFd | −60 | 78 | 91 (R) |
10 | Λ-CoCat3 (3)e | light | −50 | 91 | 80 (S) |
