Fig. 3: Enantioselective synthesis of 2,3-disubstituted piperidines. | Nature Communications

Fig. 3: Enantioselective synthesis of 2,3-disubstituted piperidines.

From: Enantioselective synthesis of chiral 2,3-cis-disubstituted piperidines and C1-substituted tetrahydroisoquinolines by asymmetric Cu-catalyzed cyclizative aminoboration

Fig. 3

aReaction conditions: 1) 1 (0.11 mmol), B2pin2 (1.5 eq.), [CuOTf]2·benzene (5 mol%), (S,S)-Ph-BPE (10 mol%), NaOMe (3 eq.), 72 h; 2) NaBO3·4H2O (5 eq.), THF/H2O (v/v = 2/1); isolated yields; ee values were determined by chiral HPLC.

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