Fig. 2: GAP domains and Ral binding of RalGAP. | Nature Communications

Fig. 2: GAP domains and Ral binding of RalGAP.

From: Structure and mechanism of the RalGAP tumor suppressor complex

Fig. 2: GAP domains and Ral binding of RalGAP.The alternative text for this image may have been generated using AI.

a Experimental structures of the Asn-Thumb GAP domain of RGα2 and b the pseudo-GAP domain of RGβ in the same orientation. c Model of GTP-bound RalA associated with RGα2 based on an AlphaFold 3 prediction. d Close-up of the active site. The catalytically relevant amino acids RGα2N1742 and RalY43 are positioned like the equivalent residues in the structure of the Rap-RapGAP complex.

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