Fig. 4: Tetramerization of RalGAP.
From: Structure and mechanism of the RalGAP tumor suppressor complex
a N-terminal homodimerization of RGβ. b Close-up of the homodimerization interface of the RGβ N-terminal domain. One RGβ subunit is shown in surface representation colored according to polarity (orange: hydrophobic, cyan: hydrophilic), the other RGβ is shown as cartoon with key interface residues shown as sticks and labeled. c Model of the RalGAP tetramer obtained by superposition of a second RGα2/RGβ heterodimer on the N-terminal HEAT domain of RGβ’ in the experimental model. d Schematic representation of the RalGAP assembly.
