Fig. 2: The free energy (FE) landscape of WT and EGFRex20ins mutations. | Nature Communications

Fig. 2: The free energy (FE) landscape of WT and EGFRex20ins mutations.

From: Poziotinib for EGFR exon 20-insertion NSCLC: Clinical efficacy of the phase 2 ZENITH trial and differential impact of EGFR exon 20 insertion location on sensitivity

Fig. 2: The free energy (FE) landscape of WT and EGFRex20ins mutations.The alternative text for this image may have been generated using AI.

a WT EGFR, (b) near-loop insertion mutants (S768dupSVD and A767dupASV), and (c) far-loop insertion mutants (H773insNPH and H773insAH). The prominent FE basins are marked as states (I–IV), and the dashed black lines denote the most probable transition path between the inactive and the active state. States I and II predominantly correspond to a Src-like inactive state and the active state, respectively, while states III and IV are the intermediate states.

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