Fig. 3: Exon 20 insertion location effects drug-receptor interactions. | Nature Communications

Fig. 3: Exon 20 insertion location effects drug-receptor interactions.

From: Poziotinib for EGFR exon 20-insertion NSCLC: Clinical efficacy of the phase 2 ZENITH trial and differential impact of EGFR exon 20 insertion location on sensitivity

Fig. 3: Exon 20 insertion location effects drug-receptor interactions.The alternative text for this image may have been generated using AI.

a, b Ribbon diagram representation of CLN-081 (purple) bound to (a) S768dupSVD and (b) H773insNPH. The black dashed line indicates the distance between the reactive acrylamide group (purple arrow) and reactive cysteine (dark blue arrow). c, d Ribbon diagram representation of mobocertinib (purple) bound to (c) S768dupSVD and (d) H773insNPH. The black dashed line indicates the distance between the reactive acrylamide group (purple arrow) and reactive cysteine (dark blue arrow).

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