Fig. 5: M. bovis frd HT insertion mutations reprogram lymph node T cell polarization toward Th17 responses. | Nature Communications

Fig. 5: M. bovis frd HT insertion mutations reprogram lymph node T cell polarization toward Th17 responses.

From: Mycobacterium bovis frd operon phase variation hijacks succinate signaling to drive immunometabolic rewiring and pathogenicity

Fig. 5

a Number of cells in draining lymph nodes of mice at 12 dpi. b, c Percentage of CD4+CD69+ T cells expressing IFN-γ or IL-17A in the draining lymph nodes of mice as in (a). d Number of cells in draining lymph nodes of mice at 22 dpi. e, f Percentage of CD4+CD69+ T cells expressing IFN-γ or IL-17A in the draining lymph nodes of mice as in (d). g, h Serum IFN-γ and IL-17A in infected mice. Data are presented as mean values  ± SD. Sample size of n  =  5 mice was included in each group. P values depicted on the graphs were assessed using one-way ANOVA with Tukey’s multiple comparisons test. WT, wild-type. Source data are provided as a Source Data file.

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