Fig. 10: Biocompatibility of Mito-G. | Nature Communications

Fig. 10: Biocompatibility of Mito-G.

From: UCP2 inhibition eliminates pancreatic β cell autoinflammation in T2DM with islet-mitochondrial sequential targeting nanomedicines

Fig. 10: Biocompatibility of Mito-G.The alternative text for this image may have been generated using AI.

A In vitro cytotoxicity of Mito-G towards INS-1 cells after incubation for 24h or 48 h (n = 3). B–F liver function indicators (B), kidney function indicators (C), and blood parameters (D–F) in normal mice (control group) and mice administered intravenously with Mito-G (5 mg/kg) 30 days after injection (n = 6). ALT: alanine aminotransferase; AST: aspartate. Aminotransferase; Scr: Serum creatinine; BUN: Blood urea nitrogen. G Representative H&E staining of major organs (heart, liver, spleen, lung, kidney) of C57 BL/6 J mice and db/m mice after injection with Mito-G (5 mg/kg) for different times. Data are presented as mean values ± SD from different biological replicates. Statistical significance was calculated by one-way ANOVA with Tukey’s post-test. Source data are provided as a Source Data file.

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