Fig. 5: Therapeutic effects of Mito-G in db/db mice. | Nature Communications

Fig. 5: Therapeutic effects of Mito-G in db/db mice.

From: UCP2 inhibition eliminates pancreatic β cell autoinflammation in T2DM with islet-mitochondrial sequential targeting nanomedicines

Fig. 5: Therapeutic effects of Mito-G in db/db mice.The alternative text for this image may have been generated using AI.

A–D The effects of Mito-G on body weight (A), food intake (B), water consumption (C), and bedding humidity (D) of mice (n  =  6). E, F The effects of Mito-G on the levels of fasting blood glucose (E), fasting blood insulin (F) (n  =  6). G, H IPGTT (G) and AUC analysis (H) of mice (n  =  6). I, J ITT (I) and AUC analysis (J) of mice (n  =  6). K, L The liver index (K), glucose-6-phatase activity (L), and glycogen phosphorylase activity (M) of different groups at 24 weeks age (n  =  6). N Representative WB of liver insulin signaling pathway related proteins. Data are presented as mean values ± SD from different biological replicates. Statistical significance was calculated by one-way ANOVA with Tukey’s post-test. Source data are provided as a Source Data file.

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