Fig. 4: Co-chaperones influence Hsp90’s conformational dynamics differently in response to ATP or AMPPNP. | Nature Communications

Fig. 4: Co-chaperones influence Hsp90’s conformational dynamics differently in response to ATP or AMPPNP.

From: ATP plays a structural role in Hsp90 function

Fig. 4

a Responses of Hsp82 alone (solid lines) or with an equimolar (to Hsp90 dimers) amount of Sti1 (dashed lines) to AMPPNP (red) or ATP (black) in the N-M docking PET assay. b The responses of Hsp82 to ATP in the presence of Sba1 (dashed black line), TMAO (dotted black line) or both Sba1 and TMAO (dotted, dashed black line) in the PET assay. The response of Hsp82 alone to AMPPNP (red) is included as a reference. For (a, b) co-chaperones and/or crowding agent was preincubated with Hsp82 before T = 0.

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