Fig. 4: Lipids reside at the dimerization interface of LYCHOS.
From: Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway
a Cryo-EM maps of LYCHOSPLD homodimer bound with lipids. The two protomers are colored in slate blue and light coral. Lipid molecules are shown in light gray. b Cryo-EM maps of LYCHOSY57A_C bound with PS. The two protomers are colored in slate blue and light coral. Two lipid molecules are colored in orange and green, respectively. c Cryo-EM density maps of PS in the LYCHOSY57A_C state are shown in blue meshes. d Details of the interaction between lipids and LYCHOS. PS and CHS molecules are shown as sticks. Residues interacting with lipids are shown in sticks. e Superimposition of the LYCHOSY57A_C structure with the map of LYCHOSY57A_TM6_E. The two protomers are colored in slate blue and light coral for LYCHOSY57A_C and lipids are shown in sticks. The lipids observed in the canonical dimer interface of LYCHOSY57A_C could not be seen in LYCHOSY57A_TM6_E.
