Fig. 1: Atrophy estimation from cross-sectional and longitudinal magnetic resonance imaging scans. | Nature Communications

Fig. 1: Atrophy estimation from cross-sectional and longitudinal magnetic resonance imaging scans.

From: Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI

Fig. 1: Atrophy estimation from cross-sectional and longitudinal magnetic resonance imaging scans.

A Illustration of the differences between cross-sectionally-estimated lifetime brain atrophy (LBA) and longitudinally-observed atrophic changes and the three distinct computational methods used to calculate brain atrophy (top panel). Illustration was created in BioRender. Fürtjes, A. (2025) https://BioRender.com/wyju63y. B The bottom panel shows MRI scans ordered top-to-bottom depicting increasingly strong signs of brain atrophy. Both visual rating scales and computational methods can be applied to estimate brain atrophy from a single neuroimaging scan such as this. Coronal and axial brain MRIs are T1-W slices of 73 year-old adults from the Lothian Birth Cohort 1936, adapted from Cox, S. R., & Deary, I. J. (2022). Brain and cognitive ageing: The present, and some predictions (…about the future). Aging Brain, 2, https://doi.org/10.1016/j.nbas.2022.100032 with permission under CC-BY 4.0.

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