Fig. 4: Genome-wide association study of lifetime brain atrophy (LBA). | Nature Communications

Fig. 4: Genome-wide association study of lifetime brain atrophy (LBA).

From: Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI

Fig. 4: Genome-wide association study of lifetime brain atrophy (LBA).

Left: Manhattan plot for LBA inferred with the residual method indicating top GWAS hits (minor allele frequency > 0.01, imputation INFO metric > 0.8) in 28 genomic loci (N = 43,110). Right: Quantile-quantile (QQ) plot indicating deviation of polygenic signal from the expected null signal on the red line. The genomic inflation factor was 1.045. Both panels were plotted with the qqman package in R34. Further evaluation and visualisation of the QQ plot in Fig. S38 shows that the step in the QQ-plot shown here disappeared when considering HapMap3 SNPs only.

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