Table 1 Genetic characteristics of lifetime brain atrophy (LBA)

From: Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI

Traits

GCTA SNP-heritability (SE)

Mean χ2a

LDSC intercept (SE)

LDSC heritability (SE)

Independent significantb GWAS hits

GWAS loci

LBA (residual score)

0.41 (0.01)

1.23

1.01 (0.008)

0.26 (0.02)

93

28

LBA (ratio score)

0.42 (0.01)

1.24

1.02 (0.009)

0.27 (0.02)

112

30

LBA (difference score)

0.47 (0.01)

1.27

1.02 (0.010)

0.30 (0.02)

128

37

Cerebrospinal fluid (CSF) volume

0.39 (0.01)

1.24

1.01 (0.009)

0.27 (0.02)

48

21

Total brain volume (TBV)

0.56 (0.01)

1.34

1.03 (0.011)

0.36 (0.03)

158

56

Intracranial volume (ICV)

0.58 (0.01)

1.35

1.03 (0.011)

0.37 (0.03)

138

45

  1. aMean χ2 calculated in HapMap3 SNPs; bGenome-wide significance threshold (two-sided association test calculated with REGENIE) = p < 5 × 10−8, independence determined at r2 < 0.6 calculated from UKB release2b 10 k European reference panel. Abbreviations: GCTA Genome-wide complex trait analysis30, SNP single-nucleotide polymorphism. LDSC linkage disequilibrium score regression31, GWAS genome-wide association study.
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