Fig. 1: Cryo-EM structure of CD163 in complex with Hb-Hp1.
From: Calcium-dependent oligomerization of scavenger receptor CD163 facilitates the endocytosis of ligands
a Domain architecture of CD163, sCD163, Hp1 and Hp2. PST, proline-serine-threonine rich interdomain segment; TM transmembrane, CCP complement control protein, SP serine protease. b Subunit organization of Hp1-1, Hp1-2 and Hp2-2 complexes. c Different views of the cryo-EM map of trimeric CD163 in complex with Hb-Hp1. Three CD163 protomers are shown in blue, cyan, and green, Hb subunits are shown in red (α) and orange (β), Hp1 is shown in pink. d Overall structure of CD163 in complex with Hb-Hp1. e Structure of CD163 SRCR domains from different viewpoints. f Model for CD163-mediated recognition and internalization of Hb-Hp complex.
