Fig. 2: Calcium-dependent oligomerization of CD163.
From: Calcium-dependent oligomerization of scavenger receptor CD163 facilitates the endocytosis of ligands
a SEC of CD163 in the presence of different concentrations of calcium. The molecular weights of CD163 estimated from SEC at different calcium concentrations (0–2.5 mM) were 150, 330, 400, 480, 500, and 500 kDa. b SV-AUC results of CD163 ectodomain in the presence of different calcium concentrations. c SEC of CD163 in the presence of 2.5 mM calcium, magnesium, barium, or strontium. d Main 2D classes of purified SRCR5-9. e Cryo-EM map of purified CD163 SRCR5-9. f Cryo-EM map of CD163 SRCR5-9 domains from the complex structure after local refinement. g Structural model of SRCR5-9 trimer. h Interactions between protomers B and C. i Interactions between protomers A and B. j Interactions between protomers A and C.
