Fig. 5: Intranasal SARS-CoV-2 infection affects the expression of genes related to neurodegenerative processes in the brainstem.

Heatmap showing the differentially expressed genes at 4- and 80-days post-infection (dpi) according to the selected KEGG pathway “Pathways of neurodegeneration” calculated comparing SARS-CoV-2 Wuhan-infected to mock-infected hamsters (two-sided test, adjusted p-values after Benjamini-Hochberg multiple testing correction, considering a false discovery rate FDR < 0.05: *, **, *** denote p < 0.05, p < 0.01 and p < 0.001 respectively). Common genes appearing in the ‘Oxidative phosphorylation pathway’ are shown in orange, whereas common genes appearing in the ‘Proteasome pathway’ are shown in green. The color gradient represents the transcription log2 fold change comparing infected and mock-infected. Gene names in bold are mentioned in the text. Related to Supplementary Fig. 6-8.