Fig. 4: Hyperpolarized 129Xe NMR and MRI performance of NiZn-ZIF-8 (nickel percentage 0.08%) at low concentrations. | Nature Communications

Fig. 4: Hyperpolarized 129Xe NMR and MRI performance of NiZn-ZIF-8 (nickel percentage 0.08%) at low concentrations.

From: Multivariate metal-organic frameworks enable chemical shift-encoded MRI with femtomolar sensitivity for biological systems

Fig. 4: Hyperpolarized 129Xe NMR and MRI performance of NiZn-ZIF-8 (nickel percentage 0.08%) at low concentrations.The alternative text for this image may have been generated using AI.

a Hyper-CEST spectra comparing NiZn-ZIF-8 (purple circle) and pristine ZIF-8 (blue circle) at the same concentration (40 μg mL-1), showing a stronger Hyper-CEST effect for NiZn-ZIF-8. b Hyper-CEST spectra of NiZn-ZIF-8 at varying concentrations (20, 30, 40, 50, and 60 μg mL-1) in aqueous solutions, highlighting the concentration-dependent increase in signal intensity. c Plot of the Hyper-CEST effect at 82 ppm as a function of NiZn-ZIF-8 concentration, demonstrating a linear relationship over the range of 20–60 μg mL-1. d Hyper-CEST MRI phantom images of NiZn-ZIF-8 at different concentrations, illustrating the dose-dependent enhancement in MRI signal intensity. Source data are provided as a Source Data file.

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