Fig. 4: Differential gene expression (DGE) analysis in SST+ cINs from the E14.5 cortex. | Nature Communications

Fig. 4: Differential gene expression (DGE) analysis in SST+ cINs from the E14.5 cortex.

From: DNMT1-mediated regulation of somatostatin-positive interneuron migration impacts cortical architecture and function

Fig. 4: Differential gene expression (DGE) analysis in SST+ cINs from the E14.5 cortex.The alternative text for this image may have been generated using AI.

Differential gene expression (DGE) analysis of FAC-sorted Sst-Cre/tdTomato (Ctrl) and Sst-Cre/tdTomato/Dnmt1 loxP2 (KO) cells isolated from the E14.5 cortex, compared to the DGE between Ctrl and KO samples from the basal telencephalon. For cortical analyses, three samples per genotype were separately processed, consisting of cells pooled from multiple embryos (Ctrl N = 7 embryos; KO N = 8 embryos). a Venn diagram illustrating the overlap between upregulated genes in KO cells from the basal telencephalon and the cortex (E14.5). b Heatmap illustrating the log2-fold change for the genes upregulated in KO cells from the basal telencephalon and the cortex. Moreover, changes in DNA methylation (from the basal telencephalon dataset) are depicted. c Gene ontology (GO) terms enriched in genes that were upregulated in E14.5 KO cells from both the basal telencephalon and the cortex. Further information: Supplementary Data 9. Raw data are available via the hyperlinks listed in the Data Availability Statement.

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