Fig. 8: Increasing 5HT1A activity with the FDA-approved drug buspirone can protect against seizures induced by sleep loss.
From: Sleep drive, not total sleep amount, increases seizure risk
a, c, d Sleep quantification after administration of caffeine demonstrates decreased sleep, but no significant change with administration of buspirone, an FDA-approved 5HT1A agonist. n = 36 flies/condition. b, e, f Seizure severity is increased with caffeine, but reduced to baseline levels with co- administration of buspirone. n = 36 flies/condition. One-way ANOVA with Dunnett’s T3 multiple comparisons test, paired two-tailed t-test, negative binomial model with Wald test (for daily number of seizures), or mixed effects model (for seizure durations) was used. Data are presented as mean values ± SEM.
