Fig. 1: Structure of the LRRK2:14-3-32 complex.
From: 14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state
a Schematic representation of LRRK2 domain organization. Residues S910 and S935, which serve as 14-3-3 binding sites upon phosphorylation, are highlighted in red. b Cryo-EM density map at a resolution of 3.96 Å (left), with the corresponding structural model shown on the right. The model is colored according to the domain color code in (a) and shown in two different orientations for clarity.
