Fig. 1: Mechanisms of +1 frameshifting by tRNAPro isoacceptors. | Nature Communications

Fig. 1: Mechanisms of +1 frameshifting by tRNAPro isoacceptors.

From: An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting

Fig. 1

a The anticodon stem-loop (ASL; 18 nucleotides) of tRNAPro isoacceptors and their corresponding anticodons (blue), including the four nucleotide codons that induce +1 frameshifting in the absence of m1G37. cmo5 denotes a 5-oxyacetic acid uridine modification. N denotes any A/U/G/C nucleotide. b The absence of m1G37 in tRNAProL induces a +1 frameshift on proline slippery codons at two defined substeps during the elongation cycle: during the EF-G-mediated translocation of peptidyl-tRNAPro isoacceptor from the A site to the P site (middle) and after translocation, when the peptidyl-tRNAPro isoacceptor is positioned in the P site but the next A-site aa-tRNA hasn’t been delivered yet (right).

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