Fig. 1: Characterization of CD8 T cell phenotype in 3xTg-AD and WT mice. | Nature Communications

Fig. 1: Characterization of CD8 T cell phenotype in 3xTg-AD and WT mice.

From: CD103–CD8+ T cells promote neurotoxic inflammation in Alzheimer’s disease via granzyme K–PAR-1 signaling

Fig. 1: Characterization of CD8 T cell phenotype in 3xTg-AD and WT mice.The alternative text for this image may have been generated using AI.

a Graphical overview of the scRNAseq experimental design created in BioRender. Terrabuio, E. (2025) https://BioRender.com/f3lmkb2. b UMAP plot showing CD45HIGH leukocytes detected in the brains and meninges of wild-type (WT; n = 8) and 3xTg-AD (n = 8) mice. CD8+ T cells (n = 3,098) are shown in red. c UMAP plots showing the five subsets of CD8+ T cells detected in the brains and meninges of WT (n = 8) and 3xTg-AD (n = 8) mice. d Bubble plot reporting the phenotypic marker genes for each CD8+ T cell subset. Transcript levels are color-coded. e Normalized expression of known marker genes on UMAP plot. Transcript levels are color-coded. f Violin plots showing the expression of marker genes for each CD8+ T cell subset. White dashed line indicates the median expression level.

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