Fig. 2: The CD8+ Trm compartment is altered in the brains of 3xTg-AD mice. | Nature Communications

Fig. 2: The CD8+ Trm compartment is altered in the brains of 3xTg-AD mice.

From: CD103–CD8+ T cells promote neurotoxic inflammation in Alzheimer’s disease via granzyme K–PAR-1 signaling

Fig. 2: The CD8+ Trm compartment is altered in the brains of 3xTg-AD mice.The alternative text for this image may have been generated using AI.

a, b Violin plots (g) and bubble plot (h) showing the expression of phenotypic markers detected by flow cytometry in the brains and meninges of WT (n = 3 pools of two organs each) and 3xTg-AD (n = 3 pools of two organs each) mice. White dashed line indicates the median expression level in violin plots (g). MFI expressions in the bubble plot (h) are scaled and color-coded. P-values are based on two-way ANOVA - multiple comparisons. Source data are provided as a Source Data file. c Donut plots indicating the distribution of CD8+ T cell subsets in the brains of WT (left) and 3xTg-AD (right) mice d Heat map showing the expression of residency genes in the brains and meninges of WT and 3xTg-AD mice. Transcript levels are color-coded. e Violin plots showing gene expression in the brains of WT (n = 8) and 3xTg-AD (n = 8) mice. f Heat map showing the expression in CD45HIGH leukocytes of genes in brains of WT (n = 8) and 3xTg- AD (n = 8) mice. Transcript levels are color-coded.

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