Fig. 7: GrK+CD103–CD8+ Trm cells accumulate in the CSF of AD patients. | Nature Communications

Fig. 7: GrK+CD103–CD8+ Trm cells accumulate in the CSF of AD patients.

From: CD103–CD8+ T cells promote neurotoxic inflammation in Alzheimer’s disease via granzyme K–PAR-1 signaling

Fig. 7: GrK+CD103–CD8+ Trm cells accumulate in the CSF of AD patients.The alternative text for this image may have been generated using AI.

a UMAP plot showing leukocyte populations detected in human CSF (n = 4 AD, n = 5 MCI, and n = 9 healthy controls, HCs) by scRNAseq. b Normalized expression of CD3E, CD8B and CD4 in the UMAP plot. Transcript levels are color-coded. c CD8+ T cell cluster subsets: UMAP plot showing KLF2+ and Trm cell subpopulations in human CSF (n = 4 AD, n = 5 MCI, and n = 9 HCs). d Normalized expression of KLF2, CD69 and PRDM1 in a UMAP plot. Transcript levels are color-coded. e Trm cell cluster subsets: UMAP plot showing CD103– and CD103+ Trm cells in human CSF (n = 4 AD, n = 5 MCI, and n = 9 HCs). f Percentage of CD103– and CD103+ CD8+ cells in human CSF (n = 4 AD, n = 5 MCI, and n = 9 HCs). Data are means ± SD. Source data are provided as a Source Data file. g Violin plot reporting GZMK expression in Trm cells of n = 4 AD patients, n = 5 MCI subjects, and n = 9 HCs. The white dot represents median expression. h Normalized expression of GZMK in a UMAP plot of all Trm cells (panel 1) and Trm cells from HCs (panel 2), MCI subjects (panel 3), and AD patients (panel 4).

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