Fig. 2: The sodium-binding site and glucose-binding site of the human SGLT2-MAP17 complex in the occluded conformation.
From: Mechanism of substrate recognition and release of human SGLT2
a The estimated surface of the hSGLT2-MAP17 complex. 4FDG and Na are shown as balls and sticks. b The electron density of the Na2 site and nearby residues, the distance between Na ion and residues are shown as yellow dashed lines, and the distances are labeled in black. c The electron density of 4FDG and nearby residues, the 4FDG is colored in orange, and the water molecules are colored in dark gray. d Interactions between 4FDG and hSGLT2. 4FDG and its interacting residues are shown as balls and sticks. Putative hydrogen bonds are depicted as black dashed lines. e A 90° rotated view of d.
