Fig. 6: Relationship between GeneXpert Ct values and LAMP test results. | Nature Communications

Fig. 6: Relationship between GeneXpert Ct values and LAMP test results.

From: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique

Fig. 6

Each data point represents results from an individual patient sample. A Comparison of GeneXpert Ct values for GeneXpert positive samples that were concordant by LAMP (True Positive: TP, n = 44 for HPV16, n = 65 for HPV18/45) or discordant by LAMP (False Negative: FN, n = 7 for HPV16, n = 9 for HPV18/45). Horizontal lines represent mean Ct values. The statistical significance in difference of means between true positive and false negative results was analyzed with an unpaired two-sided Welch’s t-test assuming Gaussian distribution and a significance level of <0.05. Differences in mean Ct values for FN and TP are statistically significant (for HPV16 p < 0.0001 and for HPV18/45 p = 0.0004). B HPV16 GeneXpert Ct value versus time to detection for the HPV16/gDNA LAMP assay (n = 39). C HPV18/45 GeneXpert Ct value versus time to detection for the HPV18/45 LAMP assay (n = 58). Higher Ct values indicate less HPV DNA. Source data are provided as a Source Data file.

Back to article page