Table 3 Rare variant-based gene-centric analysis identified lung cancer-associated genes that were replicated across different annotation categories in the replication stage and in the WES-based UK Biobank dataset)
Gene Name | Chr | Start | End | Discovery Category | Discovery P-valuea | Replication Category | Replication P-valuea | UKB Category | UKB P-valueb | Fisher P-valuec |
|---|---|---|---|---|---|---|---|---|---|---|
LRRFIP2 | 3 | 37052626 | 37183689 | Promoter | 7.72 × 10−05 | Missense | 4.47 × 10−02 | Missense | 7.19 × 10−03 | 4.26 × 10−06 |
LRRFIP2 | 3 | 37052626 | 37183689 | Promoter | 7.72 × 10−05 | Enhancer | 3.82 × 10−02 | Missense | 7.19 × 10−03 | 3.71 × 10−06 |
MRPL49 | 11 | 65122183 | 65127371 | Promoter | 2.18 × 10−04 | Enhancer | 8.29 × 10−04 | Syn | 4.44 × 10−02 | 1.55 × 10−06 |
PARPBP | 12 | 102120185 | 102197520 | Promoter | 4.11 × 10−05 | UTR | 4.93 × 10−02 | Plof | 7.07 × 10−03 | 2.61 × 10−06 |
PLA2G4C | 19 | 48047843 | 48110817 | Promoter | 5.67 × 10−05 | UTR | 1.24 × 10−02 | Synonymous | 4.43 × 10−02 | 5.22 × 10−06 |
SLC35B4 | 7 | 134289332 | 134316930 | Promoter | 1.26 × 10−04 | Downstream | 2.43 × 10−02 | Missense | 4.35 × 10−02 | 1.89 × 10−05 |
SLC35B4 | 7 | 134289332 | 134316930 | Enhancer | 5.01 × 10−05 | Downstream | 2.43 × 10−02 | Missense | 4.35 × 10−02 | 8.37 × 10−06 |
UNC13A | 19 | 17601328 | 17688365 | UTR | 6.12 × 10−05 | Enhancer | 2.14 × 10−03 | Flexdmg | 5.76 × 10−04 | 2.23 × 10−08 |
